Clinical Implications of Accurate Subtyping of Pituitary Adenomas: Perspectives from the Treating Physician

Turk Patoloji Derg. 2015:31 Suppl 1:4-17. doi: 10.5146/tjpath.2015.01311.


Pituitary adenomas comprise a heterogenous group of adenohypophyseal tumours with distinct clinicopathological features across both the clinically functioning and silent groups. Although, predicting a clinically aggressive course remains challenging, accurate subtyping of pituitary adenomas offers valuable prognostic information that together with other clinical and radiological information serves as a platform for tailored treatment and follow-up. For instance, silent subtype 3 pituitary adenomas, silent corticotroph adenomas, acidophil stem cell adenomas, Crooke cell adenomas, and sparsely granulated somatotroph adenomas show more invasive growth. This review has been formulated as a set of practical questions that address the distinct clinical behaviour of a selected group of pituitary adenoma subtypes.

Publication types

  • Review

MeSH terms

  • Adenoma / chemistry
  • Adenoma / classification
  • Adenoma / complications
  • Adenoma / pathology*
  • Adenoma / therapy
  • Biomarkers, Tumor / analysis
  • Biopsy
  • Humans
  • Immunohistochemistry
  • Magnetic Resonance Imaging
  • Pituitary Neoplasms / chemistry
  • Pituitary Neoplasms / classification
  • Pituitary Neoplasms / complications
  • Pituitary Neoplasms / pathology*
  • Pituitary Neoplasms / therapy
  • Predictive Value of Tests
  • Prognosis
  • Risk Factors


  • Biomarkers, Tumor