Syndromes that Link the Endocrine System and Genitourinary Tract

Turk Patoloji Derg. 2015:31 Suppl 1:155-71. doi: 10.5146/tjpath.2015.01322.


The endocrine system and genitourinary tract unite in various syndromes. Genitourinary malignancies may cause paraneoplastic endocrine syndromes by secreting hormonal substances. These entities include Cushing`s syndrome, hypercalcemia, hyperglycemia, polycythemia, hypertension, and inappropriate ADH or HCG production. The most important syndromic scenarios that links these two systems are hereditary renal cancer syndromes with specific genotype/phenotype correlation. There are also some very rare entities in which endocrine and genitourinary systems are involved such as Carney complex, congenital adrenal hyperplasia and Beckwith-Wiedemann syndrome. We will review all the syndromes regarding manifestations present in endocrine and genitourinary organs.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / genetics
  • Biopsy
  • Endocrine Gland Neoplasms / diagnosis*
  • Endocrine Gland Neoplasms / genetics
  • Endocrine Gland Neoplasms / pathology
  • Genetic Predisposition to Disease
  • Humans
  • Molecular Diagnostic Techniques
  • Neoplastic Syndromes, Hereditary / diagnosis*
  • Neoplastic Syndromes, Hereditary / genetics
  • Neoplastic Syndromes, Hereditary / pathology
  • Paraneoplastic Endocrine Syndromes / diagnosis*
  • Paraneoplastic Endocrine Syndromes / etiology
  • Paraneoplastic Endocrine Syndromes / pathology
  • Phenotype
  • Predictive Value of Tests
  • Prognosis
  • Urogenital Neoplasms / complications
  • Urogenital Neoplasms / diagnosis*
  • Urogenital Neoplasms / genetics
  • Urogenital Neoplasms / pathology


  • Biomarkers, Tumor