Case Study of Intrapartum Antibiotic Prophylaxis and Subsequent Postpartum Beta-Lactam Anaphylaxis

J Obstet Gynecol Neonatal Nurs. Sep-Oct 2015;44(5):610-7. doi: 10.1111/1552-6909.12732. Epub 2015 Jul 15.


Universal screening for maternal group B Streptococcus (GBS) in the prenatal period has led to administration of intrapartum antibiotic prophylaxis (IAP). Although IAP decreased the rate of early neonatal GBS disease, exposure of childbearing women to penicillin and other beta-lactam antibiotics has increased. Beta-lactam-induced anaphylaxis in the breastfeeding woman during the postpartum period illustrates risk factors for beta-lactam allergy and anaphylaxis. Treatment and nursing implications for this adverse reaction are suggested.

Keywords: anaphylaxis; beta-lactam allergy; intrapartum antibiotic prophylaxis; maternal group B Streptococcus.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects*
  • Antibiotic Prophylaxis / adverse effects*
  • Antibiotic Prophylaxis / methods
  • Female
  • Humans
  • Infectious Disease Transmission, Vertical / prevention & control
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy*
  • Puerperal Disorders / chemically induced*
  • Puerperal Disorders / therapy
  • Streptococcal Infections / prevention & control


  • Anti-Bacterial Agents