The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males

J Atten Disord. 2019 Jan;23(2):121-134. doi: 10.1177/1087054715593633. Epub 2015 Jul 15.


Objective: This study assessed the effects of citicoline, a nutraceutical, on attention, psychomotor function, and impulsivity in healthy adolescent males.

Method: Seventy-five healthy adolescent males were randomly assigned to either the citicoline group ( n = 51 with 250 or 500 mg citicoline) or placebo ( n = 24). Participants completed the Ruff 2&7 Selective Attention Test, Finger Tap Test, and the Computerized Performance Test, Second Edition (CPT-II) at baseline and after 28 days of supplementation.

Results: Individuals receiving citicoline exhibited improved attention ( p = 0.02) and increased psychomotor speed ( p = 0.03) compared with those receiving placebo. Higher weight-adjusted dose significantly predicted increased accuracy on an attention task ( p = 0.01), improved signal detectability on a computerized attention task ( p = 0.03), and decreased impulsivity ( p = 0.01).

Discussion: Adolescent males receiving 28 days of Cognizin® citicoline showed improved attention and psychomotor speed and reduced impulsivity compared to adolescent males who received placebo.

Keywords: adolescents; citicoline; cognition; cognitive enhancement.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Attention / drug effects*
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Cytidine Diphosphate Choline / therapeutic use*
  • Dietary Supplements
  • Female
  • Healthy Volunteers
  • Humans
  • Impulsive Behavior / drug effects*
  • Male
  • Nootropic Agents / therapeutic use*
  • Psychomotor Performance / drug effects*


  • Nootropic Agents
  • Cytidine Diphosphate Choline