The association between macroprolactin levels and vitamin D status in premenopausal women with macroprolactinemia: a pilot study

Exp Clin Endocrinol Diabetes. 2015 Sep;123(8):446-50. doi: 10.1055/s-0035-1555877. Epub 2015 Jul 15.


Background: Macroprolactinemia is a frequent cause of misdiagnosis and mismanagement of patients with elevated prolactin levels. Its pathogenesis and clinical significance are still controversial.

Methods: The aim of this study was to investigate the relationship between elevated macroprolactin content and vitamin D status. The study population included 20 premenopausal women with isolated macroprolactinemia, 10 of whom were later treated with vitamin D (2 000 IU daily). Serum prolactin, macroprolactin, 25-hydroxyvitamin D and PTH levels were assessed at baseline and after 4 months of treatment.

Results: Compared with the control age- and weight-women with normal prolactin levels (n=11), patients with macroprolactinemia were characterized by lower levels of 25-hydroxyvitamin D and slightly higher levels of PTH. Vitamin D administered to patients with macroprolactinemia increased 25-hydroxyvitamin, reduced total prolactin and macroprolactin, as well tended to reduce PTH. The effect of vitamin D on total prolactin and macroprolactin correlated with their baseline values and baseline 25-hydroxyvitamin D levels.

Conclusions: The results of our study suggest the association between vitamin D status and elevated macroprolactin levels in premenopausal women.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Hyperprolactinemia / blood*
  • Pilot Projects
  • Prolactin / blood*
  • Vitamin D / blood*


  • prolactin, polymeric
  • Vitamin D
  • Prolactin