CD4 Response Up to 5 Years After Combination Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Patients in Latin America and the Caribbean

Open Forum Infect Dis. 2015 Jun 5;2(2):ofv079. doi: 10.1093/ofid/ofv079. eCollection 2015 Apr.


We describe CD4 counts at 6-month intervals for 5 years after combination antiretroviral therapy initiation among 12 879 antiretroviral-naive human immunodeficiency virus-infected adults from Latin America and the Caribbean. Median CD4 counts increased from 154 cells/mm(3) at baseline (interquartile range [IQR], 60-251) to 413 cells/mm(3) (IQR, 234-598) by year 5.

Keywords: HIV/AIDS; Latin America and the Caribbean; cART; cohort; combination antiretroviral therapy; immune recovery; inverse probability of censoring weights.