Comparison of swept source optical coherence tomography and spectral domain optical coherence tomography in polypoidal choroidal vasculopathy

Clin Exp Ophthalmol. 2015 Dec;43(9):815-9. doi: 10.1111/ceo.12580. Epub 2015 Aug 6.


Background: Swept source optical coherence tomography (SS-OCT, Topcon Medical System, Japan) is known to have longer wavelength than spectral domain OCT (SD-OCT, Spectralis, Heidelberg Engineering, Germany), allowing a deeper penetration into retina and choroidal layers. This objective of this study was to compare the visibility of retinal and choroidal features in polypoidal choroidal vasculopathy (PCV) using SS-OCT and SD-OCT.

Design: This study employs prospective comparative observational case series in Singapore National Eye Center.

Participants: There were 20 eyes (20 patients) with PCV confirmed with indocyanine green angiogram.

Methods: Six pre-specified OCT parameters (presence of polyps, sharp pigment epithelial detachment [PED] peak, notched PED and visibility of full maximum height of PED, inner segment/outer segment [IS/OS] line and choroid-scleral interface [CSI]) were graded using SS-OCT and SD-OCT.

Main outcome measures: The Kappa statistics between the two imaging modalities were calculated.

Results: Both SS-OCT and SD-OCT were able to detect polypoidal lesions in the majority of eyes (90% and 85%, respectively). However, SS-OCT had better detection for CSI and IS/OS lines (CSI: 80% vs 45%, P = 0.05; IS/OS line: 65% vs 45%, P = 0.34). For sharp PED peak, notched PED, ability to visualize the full PED height and retinal pigment epithelial line, both OCT machines were able to detect in ≥80% of the eyes.

Conclusion: In conclusion, SS-OCT and SD-OCT appeared to be similarly effective at detecting most features associated with PCV. However, SS-OCT is more superior in detecting the CSI.

Keywords: polyp; polypoidal choroidal vasculopathy; swept source optical coherence tomography.

Publication types

  • Comparative Study
  • Observational Study

MeSH terms

  • Aged
  • Choroid / pathology*
  • Choroidal Neovascularization / diagnosis*
  • Coloring Agents / administration & dosage
  • Female
  • Fluorescein Angiography
  • Humans
  • Indocyanine Green / administration & dosage
  • Male
  • Middle Aged
  • Polyps / diagnosis*
  • Prospective Studies
  • Retina / pathology*
  • Tomography, Optical Coherence* / instrumentation


  • Coloring Agents
  • Indocyanine Green