Eosinophil-Derived Neurotoxin (EDN/RNase 2) and the Mouse Eosinophil-Associated RNases (mEars): Expanding Roles in Promoting Host Defense

Int J Mol Sci. 2015 Jul 8;16(7):15442-55. doi: 10.3390/ijms160715442.


The eosinophil-derived neurotoxin (EDN/RNase2) and its divergent orthologs, the mouse eosinophil-associated RNases (mEars), are prominent secretory proteins of eosinophilic leukocytes and are all members of the larger family of RNase A-type ribonucleases. While EDN has broad antiviral activity, targeting RNA viruses via mechanisms that may require enzymatic activity, more recent studies have elucidated how these RNases may generate host defense via roles in promoting leukocyte activation, maturation, and chemotaxis. This review provides an update on recent discoveries, and highlights the versatility of this family in promoting innate immunity.

Keywords: chemoattractant; evolution; inflammation; leukocyte.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Cytokines / metabolism
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism
  • Eosinophil-Derived Neurotoxin / classification
  • Eosinophil-Derived Neurotoxin / genetics
  • Eosinophil-Derived Neurotoxin / metabolism*
  • Eosinophils / immunology
  • Eosinophils / metabolism*
  • Hepatitis B virus / drug effects
  • Humans
  • Immunity, Innate
  • Phylogeny
  • Recombinant Proteins / biosynthesis
  • Recombinant Proteins / chemistry
  • Recombinant Proteins / pharmacology


  • Cytokines
  • Recombinant Proteins
  • Ear2 protein, mouse
  • Eosinophil-Derived Neurotoxin