Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative

Circ Res. 2015 Jul 17;117(3):234-8. doi: 10.1161/CIRCRESAHA.117.306693.


Mitochondrial biology is the sum of diverse phenomena from molecular profiles to physiological functions. A mechanistic understanding of mitochondria in disease development, and hence the future prospect of clinical translations, relies on a systems-level integration of expertise from multiple fields of investigation. Upon the successful conclusion of a recent National Institutes of Health, National Heart, Lung, and Blood Institute initiative on integrative mitochondrial biology in cardiovascular diseases, we reflect on the accomplishments made possible by this unique interdisciplinary collaboration effort and exciting new fronts on the study of these remarkable organelles.

Keywords: National Heart, Lung, and Blood Institute (U.S.); cardiovascular disease; cell death; heart diseases; mitochondria.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cooperative Behavior
  • Forecasting
  • Government Programs / organization & administration*
  • Heart Diseases / metabolism
  • Heart Diseases / physiopathology*
  • Heart Diseases / therapy
  • Humans
  • Interdisciplinary Communication
  • Inventions
  • Medical Informatics Computing
  • Mitochondria, Heart / physiology*
  • Models, Cardiovascular
  • Myocytes, Cardiac / physiology*
  • Myocytes, Cardiac / ultrastructure
  • National Heart, Lung, and Blood Institute (U.S.) / organization & administration*
  • Program Evaluation
  • Systems Biology
  • Therapies, Investigational
  • Translational Research, Biomedical
  • United States
  • Universities