Community-Acquired Pyelonephritis in Pregnancy Caused by KPC-Producing Klebsiella pneumoniae

Antimicrob Agents Chemother. 2015 Aug;59(8):4375-8. doi: 10.1128/AAC.00553-15.

Abstract

Carbapenem-resistant Enterobacteriaceae (CRE) usually infect patients with significant comorbidities and health care exposures. We present a case of a pregnant woman who developed community-acquired pyelonephritis caused by KPC-producing Klebsiella pneumoniae. Despite antibiotic treatment, she experienced spontaneous prolonged rupture of membranes, with eventual delivery of a healthy infant. This report demonstrates the challenge that CRE may pose to the effective treatment of common infections in obstetric patients, with potentially harmful consequences to maternal and neonatal health.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Proteins / metabolism*
  • Carbapenems / therapeutic use
  • Community-Acquired Infections / drug therapy
  • Community-Acquired Infections / microbiology*
  • Female
  • Humans
  • Infant
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / metabolism
  • Klebsiella pneumoniae / pathogenicity*
  • Pregnancy
  • Pyelonephritis / microbiology*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems