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Randomized Controlled Trial
, 21 (26), 8184-94

Intraprocedural Bowel Cleansing With the JetPrep Cleansing System Improves Adenoma Detection

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Randomized Controlled Trial

Intraprocedural Bowel Cleansing With the JetPrep Cleansing System Improves Adenoma Detection

Arthur Hoffman et al. World J Gastroenterol.

Abstract

Aim: To investigate the impact of JetPrep cleansing on adenoma detection rates.

Methods: In this prospective, randomized, crossover trial, patients were blindly randomized to an intervention arm or a control arm. In accordance with the risk profile for the development of colorectal carcinoma, the study participants were divided into high-risk and low-risk groups. Individuals with just one criterion (age > 70 years, adenoma in medical history, and first-degree relative with colorectal cancer) were regarded as high-risk patients. Bowel preparation was performed in a standardized manner one day before the procedure. Participants in the intervention arm underwent an initial colonoscopy with standard bowel cleansing using a 250-mL syringe followed by a second colonoscopy that included irrigation by the use of the JetPrep cleansing system. The reverse sequence was used in the control arm. The study participants were divided into a high-risk group and a low-risk group according to their respective risk profiles for the development of colorectal carcinoma.

Results: A total of 64 patients (34 men and 30 women) were included in the study; 22 were included in the high-risk group. After randomization, 30 patients were assigned to the control group (group A) and 34 to the intervention group (group B). The average Boston Bowel Preparation Scale score was 5.15 ± 2.04. The withdrawal time needed for the first step was significantly longer in group A using the JetPrep system (9.41 ± 3.34 min) compared to group B (7.5 ± 1.92 min). A total of 163 polyps were discovered in 64 study participants who underwent both investigation steps. In group A, 49.4% of the polyps were detected during the step of standard bowel cleansing while the miss rate constituted 50.7%. Group B underwent cleansing with the JetPrep system during the first examination step, and as many as 73.9% of polyps were identified during this step. Thus, the miss rate in group B was a mere 26.1% (P < 0.001). When considering only the right side of the colon, the miss rate in group A during the first examination was 60.6%, in contrast to a miss rate of 26.4% in group B (P < 0.001).

Conclusion: JetPrep is recommended for use during colonoscopy because a better prepared bowel enables a better adenoma detection, particularly in the proximal colon.

Keywords: Adenoma detection rate; Adenoma miss rate; Boston Bowel Preparation Scale; Colon preparation; Flat adenoma; Interval cancer; Right sided colon.

Figures

Figure 1
Figure 1
JetPrep system.
Figure 2
Figure 2
Miss rates for polyps, adenomas and sessile serrated adenomas. SSA: Sessile serrated adenoma.
Figure 3
Figure 3
Miss rates for polyps, adenomas and sessile serrated adenomas on the right side of the colon. SSA: Sessile serrated adenomas.
Figure 4
Figure 4
Total number of found adenomas and sessile serrated adenomas.
Figure 5
Figure 5
Number of right-sided adenomas and sessile serrated adenomas.

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