Visual Acuity in Birdshot Retinochoroidopathy Evaluation

Am J Ophthalmol. 2015 Oct;160(4):817-21.e2. doi: 10.1016/j.ajo.2015.07.008. Epub 2015 Jul 17.


Purpose: To determine the statistical correlation between visual acuity (VA) and various quantitative parameters relevant to birdshot retinochoroidopathy (BRC) evaluation.

Design: Hospital-based retrospective observational study.

Methods: setting: Institutional.

Study population: Consecutive HLA29+ BRC patients were included between May and August 2013 at a single tertiary center (Pitié-Salpétrière Hospital, Paris).

Observation procedures: Demographic data and quantitative parameters relevant to BRC at baseline were collected: VA, degree of anterior and posterior inflammatory reaction, foveal thickness measured by optical coherence tomography (OCT), Arden ratio, and electrooculography (EOG) light peak.

Main outcome measures: Correlation between VA and the other parameters of the ipsilateral and fellow eye was performed using Spearman rank correlation coefficients.

Results: Fifty-five patients were included. Mean VA was 6/9.5 in the right eye (OD) and 6/12 in the left eye (OS). Mean foveal thickness was 240 μm OD (range: 112-606) and 251 μm OS (range: 85-662). Mean Arden ratio was 159% OD and 160% OS. EOG light peak was 714 mV OD (range: 316-1379) and 746 mV OS (range: 272-1652). VA of a given eye was moderately correlated with VA of the contralateral eye (r = 0.4). On the contrary, all other parameters showed a strong correlation between both eyes (all r > 0.7, P < .01). Overall, none of the studied parameters was correlated with its VA (all r < 0.5).

Conclusion: In BRC, visual acuity alone does not seem to fully reflect the disease severity in terms of clinical or ancillary quantitative findings at baseline.

Publication types

  • Observational Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Birdshot Chorioretinopathy
  • Chorioretinitis / drug therapy
  • Chorioretinitis / metabolism
  • Chorioretinitis / physiopathology*
  • Electrooculography
  • Female
  • Glucocorticoids / therapeutic use
  • HLA-A Antigens / metabolism
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Middle Aged
  • Retrospective Studies
  • Tomography, Optical Coherence
  • Visual Acuity / physiology*
  • Visual Field Tests


  • Glucocorticoids
  • HLA-A Antigens
  • HLA-A29 antigen
  • Immunosuppressive Agents