The emergence of metabolomics as a key discipline in the drug discovery process

Drug Discov Today Technol. 2015 Jun;13:19-24. doi: 10.1016/j.ddtec.2015.01.006. Epub 2015 Feb 28.

Abstract

Metabolomics is a recent science that could be defined as the comprehensive qualitative and quantitative analysis of all small molecular weight compounds present in a cell, organ (including biofluids) or organism at a specific time point. More and more applications have been found these past years to metabolomics in the pharmaceutical field. Specifically in the drug discovery process, metabolomics open new perspectives, in new targets identification, in toxicological studies and in bioactive natural products discovery. The challenge in metabolomics is to find a technological approach allowing the reproducible identification and quantitation of as much metabolites as possible. In this context, mass spectrometry and NMR are emerging as key and complementary technologies.

Publication types

  • Review

MeSH terms

  • Chromatography, High Pressure Liquid*
  • Drug Discovery / methods*
  • Drug Discovery / trends
  • Humans
  • Magnetic Resonance Spectroscopy*
  • Mass Spectrometry*
  • Metabolomics / methods*
  • Metabolomics / trends