Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 7, 121
eCollection

Terra Incognita-Cerebellar Contributions to Neuropsychiatric and Cognitive Dysfunction in Behavioral Variant Frontotemporal Dementia

Affiliations

Terra Incognita-Cerebellar Contributions to Neuropsychiatric and Cognitive Dysfunction in Behavioral Variant Frontotemporal Dementia

Rachel H Tan et al. Front Aging Neurosci.

Abstract

Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioral variant frontotemporal dementia (bvFTD), a disease which is characterized by cognitive and neuropsychiatric deficits. The present study assessed whether degeneration in specific cerebellar subregions associate with indices of cognition and neuropsychiatric performance in bvFTD. Our results demonstrate a relationship between cognitive and neuropsychiatric decline across various domains of memory, language, emotion, executive, visuospatial function, and motivation and the degree of gray matter degeneration in cerebellar lobules V-VII. Most notably, bilateral cerebellar lobule VII and the posterior vermis emerged as distinct for memory processes, the right cerebellar hemisphere underpinned emotion, and the posterior vermis was highlighted in language dysfunction in bvFTD. Based on cortico-cerebellar connectivity maps, these findings in the cerebellum are consistent with the neural connections with the cortices involved in these domains in patients with bvFTD. Overall, the present study underscores the significance of cortical-cerebellar networks associated with cognition and neuropsychiatric dysfunction in bvFTD.

Keywords: behavioral variant frontotemporal dementia; cerebellum; cognition; neural correlates; neuropsychiatric processes.

Figures

Figure 1
Figure 1
Voxel-based morphometry analyses showing cerebellar regions in which gray matter intensity correlates significantly with memory, language, executive, emotion, visuospatial task performance, and motivation measures across all participant groups. Colored voxels show regions that were significant in the analyses for p < 0.01 uncorrected and a cluster threshold of 20 contiguous voxels. All clusters reported t > 3.5. Clusters are overlaid on the MNI standard brain with a mask for lobule VII (crus 1, 2, and VIIb) shown in blue and a mask for the vermis shown in light blue. L, Left Hemisphere; R, Right Hemisphere.
Figure 2
Figure 2
Voxel-based morphometry analyses showing overlapping regions of cerebellar gray matter atrophy for memory, language, emotion, executive, and visuospatial performances across all participants. Colored voxels show regions that were significant in the analyses for p < 0.01 uncorrected and a cluster threshold of 20 contiguous voxels. All clusters reported t > 3.5. Clusters are overlaid on the MNI standard brain with a mask for lobule VII (crus 1, 2, and VIIb) shown in blue and a mask for the vermis shown in light blue. L, Left Hemisphere; R, Right Hemisphere.
Figure 3
Figure 3
Voxel-based morphometry analyses showing exclusive regions of cerebellar gray matter correlates for memory, language, emotion, executive, and visuospatial performances across all participants. Colored voxels show regions that were significant in the analyses for p < 0.01 uncorrected and a cluster threshold of 20 contiguous voxels. All clusters reported t > 3.5. Clusters are overlaid on the MNI standard brain with a mask for lobule VII (crus 1, 2, and VIIb) shown in blue and a mask for the vermis shown in light blue. L, Left Hemisphere; R, Right Hemisphere.

Similar articles

See all similar articles

Cited by 3 PubMed Central articles

References

    1. Andersson J. L. R., Jenkinson M., Smith S. (2007a). Non-linear optimisation FMRIB Technial Report TR07JA1. Oxford: FMRIB Centre.
    1. Bak T. H., Hodges J. R. (2001). Motor neurone disease, dementia and aphasia: coincidence, co-occurrence or continuum? J. Neurol. 248, 260–270. 10.1007/s004150170199 - DOI - PubMed
    1. Baumann O., Mattingley J. B. (2012). Functional topography of primary emotion processing in the human cerebellum. Neuroimage 61, 805–811. 10.1016/j.neuroimage.2012.03.044 - DOI - PubMed
    1. Bertoux M., Volle E., De Souza L. C., Funkiewiez A., Dubois B., Habert M. O. (2014). Neural correlates of the mini-SEA (social cognition and emotional assessment) in behavioral variant frontotemporal dementia. Brain Imaging Behav. 8, 1–6. 10.1007/s11682-013-9261-0 - DOI - PubMed
    1. Brooks B. R., Miller R. G., Swash M., Munsat T. L. (2000). El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 1, 293–299. 10.1080/146608200300079536 - DOI - PubMed

LinkOut - more resources

Feedback