Sesamin ameliorates oxidative liver injury induced by carbon tetrachloride in rat

Int J Clin Exp Pathol. 2015 May 1;8(5):5733-8. eCollection 2015.


Sesamin is naturally occurring lignan from sesame oil with putative antioxidant property. The present study was designed to investigate the protective role of sesamin against carbon tetrachloride induced oxidative liver injury. Male Wistar albino rats (180-200 g) were divided in to 5 groups (n=6). Hepatotoxicity was induced by the administration of CCl4 (0.1 ml/100 g bw., 50% v/v with olive oil) intraperitoneally. Sesamin was administered in two different dose (5 and 10 ml/kg bw) to evaluate the hepatoprotective activity. Sesamin significantly reduced the elevated serum liver marker enzymes (P<0.0001). Reduction of TBARS (P<0.01 and P<0.001) followed by enhancement of GSH., SOD and catalase (P<0.0001) in liver homogenate in sesamin treated groups shows the amelioration of oxidative stress induced by CCl4. Histopathological report also supported the hepatoprotection offered by sesamin. Sesamin effects in both the dose were in comparable to reference standard drug silymarin. From these above findings it has been concluded that sesamin ameliorate the oxidative liver injury in terms of reduction of lipid peroxidation and enhancement of liver antioxidant enzymes.

Keywords: Liver injury; hepatotoxin; nutraceuticals; oxidative stress; sesame lignan.

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Carbon Tetrachloride / toxicity
  • Chemical and Drug Induced Liver Injury / prevention & control*
  • Dioxoles / pharmacology*
  • Disease Models, Animal
  • Lignans / pharmacology*
  • Lipid Peroxidation / drug effects
  • Male
  • Oxidative Stress / drug effects
  • Rats
  • Rats, Wistar


  • Antioxidants
  • Dioxoles
  • Lignans
  • Carbon Tetrachloride
  • sesamin