Comparison of the Effect of Thiazide Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross-Sectional Analysis Among Nondiabetic Patients

J Clin Hypertens (Greenwich). 2015 Nov;17(11):848-54. doi: 10.1111/jch.12622. Epub 2015 Jul 20.


Thiazide diuretics (TDs) are a cost-effective first-line therapy for uncomplicated hypertension; however, they are less prescribed than other options. The authors aimed to assess the noninferiority of TDs relative to different classes of antihypertensive medications in relation to central blood pressure. Cross-sectional data from the Quebec CARTaGENE project was used. Nondiabetic hypertensive participants on monotherapy for hypertension were studied. Separate adjusted models were constructed to establish noninferiority of TDs to non-TD antihypertensive medications for central blood pressure measurements. Models included a set of potential confounders. Of the 1194 hypertensive participants, 7.4% were taking TDs. We found that TDs were comparable with non-TD antihypertensive medications for central systolic blood pressure (adjusted regression coefficient, 0.45; 95% confidence interval, -1.61 to 2.50). No differences in other central measurements were noted. The results provide additional support that TDs are at least as effective as other first-line medications for treating uncomplicated hypertension.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antihypertensive Agents / pharmacology*
  • Blood Pressure / drug effects*
  • Blood Pressure Determination
  • Cross-Sectional Studies
  • Female
  • Humans
  • Hypertension / drug therapy
  • Male
  • Middle Aged
  • Prospective Studies
  • Sodium Chloride Symporter Inhibitors / pharmacology*


  • Antihypertensive Agents
  • Sodium Chloride Symporter Inhibitors