Alzheimer's Disease Neuroimaging Initiative 2 Clinical Core: Progress and plans

Alzheimers Dement. 2015 Jul;11(7):734-9. doi: 10.1016/j.jalz.2015.05.005.


Introduction: This article reviews the current status of the Clinical Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI), and summarizes planning for the next stage of the project.

Methods: Clinical Core activities and plans were synthesized based on discussions among the Core leaders and external advisors.

Results: The longitudinal data in ADNI-2 provide natural history data on a clinical trials population and continue to inform refinement and standardization of assessments, models of trajectories, and clinical trial methods that have been extended into sporadic preclinical Alzheimer's disease (AD).

Discussion: Plans for the next phase of the ADNI project include maintaining longitudinal follow-up of the normal and mild cognitive impairment cohorts, augmenting specific clinical cohorts, and incorporating novel computerized cognitive assessments and patient-reported outcomes. A major hypothesis is that AD represents a gradually progressive disease that can be identified precisely in its long presymptomatic phase, during which intervention with potentially disease-modifying agents may be most useful.

Keywords: Alzheimer's disease; Amyloid; Cognitive assessment.

Publication types

  • Historical Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Age Factors
  • Alzheimer Disease / complications
  • Alzheimer Disease / diagnosis*
  • Clinical Trials as Topic / history
  • Clinical Trials as Topic / methods*
  • Cognition Disorders / diagnosis
  • Cognition Disorders / etiology
  • Computer Communication Networks
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Longitudinal Studies
  • Neuroimaging* / history
  • Neuroimaging* / methods
  • Neuroimaging* / standards