Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014

Alzheimers Dement. 2015 Jul;11(7):865-84. doi: 10.1016/j.jalz.2015.04.005.


Introduction: The Alzheimer's Disease Neuroimaging Initiative (ADNI) was established in 2004 to facilitate the development of effective treatments for Alzheimer's disease (AD) by validating biomarkers for AD clinical trials.

Methods: We searched for ADNI publications using established methods.

Results: ADNI has (1) developed standardized biomarkers for use in clinical trial subject selection and as surrogate outcome measures; (2) standardized protocols for use across multiple centers; (3) initiated worldwide ADNI; (4) inspired initiatives investigating traumatic brain injury and post-traumatic stress disorder in military populations, and depression, respectively, as an AD risk factor; (5) acted as a data-sharing model; (6) generated data used in over 600 publications, leading to the identification of novel AD risk alleles, and an understanding of the relationship between biomarkers and AD progression; and (7) inspired other public-private partnerships developing biomarkers for Parkinson's disease and multiple sclerosis.

Discussion: ADNI has made myriad impacts in its first decade. A competitive renewal of the project in 2015 would see the use of newly developed tau imaging ligands, and the continued development of recruitment strategies and outcome measures for clinical trials.

Keywords: AD biomarker signature; Alzheimer's disease; Amyloid phenotyping; Clinical trial biomarkers; Data-sharing; Tau imaging; Worldwide ADNI.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alzheimer Disease / diagnosis*
  • Alzheimer Disease / therapy*
  • Biomarkers
  • Clinical Trials as Topic
  • Databases, Bibliographic / statistics & numerical data
  • Disease Progression
  • Humans
  • Longitudinal Studies
  • Neuroimaging / methods*


  • Biomarkers