Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women

J Assist Reprod Genet. 2015 Sep;32(9):1305-11. doi: 10.1007/s10815-015-0538-7. Epub 2015 Jul 21.


Objective: Previous studies regarding the effect of obesity on serum anti-müllerian hormone (AMH) levels have been conflicting. Our aim was to determine the effect of obesity on serum AMH levels among women from different racial backgrounds.

Methods: The medical records of 350 women (159 Caucasian, 99 African-American, 58 Hispanic, 34 Asian with ages 16-46) evaluated for infertility at an academic-affiliated center and who had AMH levels measured as part of their evaluation were reviewed. Age, AMH, body mass index (BMI), self-reported race, etiology of infertility, smoking history, maximum serum early follicular follicle-stimulating hormone (FSH) levels, antral follicle count (AFC), and history of ovarian surgery, chemotherapy, or radiotherapy were recorded.

Results: Age correlated negatively with AMH and antral follicle count across all races (p < 0.05). After adjusting for age, polycystic ovary syndrome diagnosis, and smoking, elevated BMI had a negative correlation with AMH in Caucasian women (β = 0.17, p = 0.01) but not in African-American, Hispanic, or Asian women.

Conclusion: Elevated BMI correlates negatively with AMH in Caucasian women but not in African-American, Hispanic, or Asian women. Additional studies are needed to elucidate further the effect of race on the interaction between obesity and ovarian reserve.

Keywords: Anti-müllerian hormone (AMH); Body mass index; Obesity; Race/ethnicity.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Anti-Mullerian Hormone / blood*
  • Biomarkers / blood*
  • Body Mass Index
  • European Continental Ancestry Group / statistics & numerical data*
  • Female
  • Follicle Stimulating Hormone / blood
  • Follow-Up Studies
  • Humans
  • Immunoassay
  • Infertility / blood
  • Infertility / diagnosis*
  • Infertility / etiology
  • Middle Aged
  • Obesity / complications*
  • Obesity / ethnology
  • Obesity / physiopathology
  • Polycystic Ovary Syndrome / complications*
  • Polycystic Ovary Syndrome / ethnology
  • Polycystic Ovary Syndrome / physiopathology
  • Pregnancy
  • Prognosis
  • Smoking / adverse effects
  • Young Adult


  • Biomarkers
  • Anti-Mullerian Hormone
  • Follicle Stimulating Hormone