Abstract
Fungal infections, especially infections caused by Candida albicans, remain a challenging problem in clinical settings. Despite the development of more-effective antifungal drugs, their application is limited for various reasons. Thus, alternative treatments with drugs aimed at novel targets in C. albicans are needed. Knowledge of growth and virulence in fungal cells is essential not only to understand their pathogenic mechanisms but also to identify potential antifungal targets. This article reviews the current knowledge of the mechanisms of growth and virulence in C. albicans and examines potential targets for the development of new antifungal drugs.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antifungal Agents / chemical synthesis
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Antifungal Agents / pharmacology*
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Biofilms / drug effects
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Biofilms / growth & development
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Calcium Signaling / drug effects
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Candida albicans / drug effects*
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Candida albicans / genetics
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Candida albicans / metabolism
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Candida albicans / pathogenicity
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Candidiasis / drug therapy*
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Candidiasis / microbiology
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Drug Discovery
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Drug Resistance, Fungal*
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Gene Expression Regulation, Fungal*
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Glyoxylates / antagonists & inhibitors
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Glyoxylates / metabolism
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Humans
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Hydrolases / antagonists & inhibitors
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Hydrolases / genetics
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Hydrolases / metabolism
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Molecular Targeted Therapy
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Osmolar Concentration
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Peptides, Cyclic / chemical synthesis
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Peptides, Cyclic / pharmacology*
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TOR Serine-Threonine Kinases / antagonists & inhibitors
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TOR Serine-Threonine Kinases / genetics
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TOR Serine-Threonine Kinases / metabolism
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Transcription Factors / antagonists & inhibitors
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Virulence
Substances
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Antifungal Agents
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Glyoxylates
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Peptides, Cyclic
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Transcription Factors
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TOR Serine-Threonine Kinases
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Hydrolases
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glyoxylic acid