A Facile FeCl3/I2-Catalyzed Aerobic Oxidative Coupling Reaction: Synthesis of Tetrasubstituted Imidazoles from Amidines and Chalcones

Org Lett. 2015 Aug 7;17(15):3872-5. doi: 10.1021/acs.orglett.5b01854. Epub 2015 Jul 21.

Abstract

A facile and efficient route for the synthesis of tetrasubstituted imidazoles from amidines and chalcones via FeCl3/I2-catalyzed aerobic oxidative coupling has been developed. This new strategy is featured by high regioselectivity and yields, good functional group tolerance, and mild reaction conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amidines / chemistry*
  • Catalysis
  • Chalcones / chemistry*
  • Chlorides / chemistry*
  • Ferric Compounds / chemistry*
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Iodine / chemistry*
  • Molecular Structure
  • Oxidative Coupling

Substances

  • Amidines
  • Chalcones
  • Chlorides
  • Ferric Compounds
  • Imidazoles
  • Iodine
  • ferric chloride