The promise and peril of chemical probes

Nat Chem Biol. 2015 Aug;11(8):536-41. doi: 10.1038/nchembio.1867.


Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

MeSH terms

  • Biomedical Research / instrumentation
  • Biomedical Research / methods*
  • Humans
  • Information Dissemination / ethics*
  • Intellectual Property
  • Internet
  • Molecular Probes / chemistry*
  • Molecular Probes / pharmacology
  • Molecular Weight
  • Sensitivity and Specificity
  • Small Molecule Libraries / chemistry*
  • Small Molecule Libraries / pharmacology


  • Molecular Probes
  • Small Molecule Libraries