Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Aug;21(8):1462-5.
doi: 10.3201/eid2108.150060.

Infections With Candidatus Neoehrlichia Mikurensis and Cytokine Responses in 2 Persons Bitten by Ticks, Sweden

Free PMC article
Case Reports

Infections With Candidatus Neoehrlichia Mikurensis and Cytokine Responses in 2 Persons Bitten by Ticks, Sweden

Anna Grankvist et al. Emerg Infect Dis. .
Free PMC article

Abstract

The prevalence of Candidatus Neoehrlichia mikurensis infection was determined in 102 persons bitten by ticks in Sweden. Two infected women had erythematous rashes; 1 was co-infected with a Borrelia sp., and the other showed seroconversion for Anaplasma phagocytophilum. Both patients had increased levels of Neoehrlichia DNA and serum cytokines for several months.

Keywords: Anaplasma phagocytophilum; Anaplasmataceae; Borrelia burgdorferi sensu lato; Candidatus Neoehrlichia mikurensis; Sweden; bacteria; cytokine responses; erythema; immunocompetence; tick-borne infections; ticks; vector-borne infections.

Figures

Figure 1
Figure 1
Proinflammatory cytokines in 2 patients infected with Candidatus Neoehrlichia mikurensis, Sweden. Concentrations of cytokines A) interleukin-1β (IL-1β), B) tumor necrosis factor-α (TNF-α), C) interleukin-6 (IL-6), and D) macrophage inflammatory protein-1β (MIP-1β) were measured in serum of patient 1 on days 0, 77, and 169 and in serum of patient 2 on days 0, 65, and 98. A rash developed in patient 1 on day 77 and in patient 2 on day 65. Dashed lines indicate levels of Neoehrlichia DNA in plasma for both patients. Dotted lines indicate detection limit for each cytokine.
Figure 2
Figure 2
Th1 cytokines in 2 patients infected with Candidatus Neoehrlichia mikurensis, Sweden. Concentrations of cytokines A) interleukin-12p70 (IL-12p70), B) interferon-γ (IFN-γ), C) monocyte chemoattractant protein-1 (MCP-1) (C), and D) IFN-γ−induced protein 10 (IP-10) were measured in serum of patient 1 on days 0, 77, and 169 and in serum of patient 2 on days 0, 65, and 98. Dashed lines indicate levels of Neoehrlichia DNA in plasma for both patients. Dotted lines indicate detection limit for each cytokine.

Similar articles

See all similar articles

Cited by 8 articles

See all "Cited by" articles

References

    1. Wenneras C. Infections with the tick-borne bacterium Candidatus Neoehrlichia mikurensis. Clin Microbiol Infect. 2015. Mar 11:pii: S1198-743X(15)00324-9.
    1. Grankvist A, Andersson PO, Mattsson M, Sender M, Vaht K, Hoper L, et al. Infections with the tick-borne bacterium “Candidatus Neoehrlichia mikurensis” mimic noninfectious conditions in patients with B cell malignancies or autoimmune diseases. Clin Infect Dis. 2014;58:1716–22 . 10.1093/cid/ciu189 - DOI - PubMed
    1. Welc-Faleciak R, Sinski E, Kowalec M, Zajkowska J, Pancewicz SA. Asymptomatic “Candidatus Neoehrlichia mikurensis” infections in immunocompetent humans. J Clin Microbiol. 2014;52:3072–4. 10.1128/JCM.00741-14 - DOI - PMC - PubMed
    1. Fehr JS, Bloemberg GV, Ritter C, Hombach M, Luscher TF, Weber R, et al. Septicemia caused by tick-borne bacterial pathogen Candidatus Neoehrlichia mikurensis. Emerg Infect Dis. 2010;16:1127–9. 10.3201/eid1607.091907 - DOI - PMC - PubMed
    1. Li H, Jiang JF, Liu W, Zheng YC, Huo QB, Tang K, et al. Human infection with Candidatus Neoehrlichia mikurensis, China. Emerg Infect Dis. 2012;18:1636–9. 10.3201/eid1810.120594 - DOI - PMC - PubMed

Publication types

LinkOut - more resources

Feedback