Abstract
A new diketopiperazine (DKP) derivative, (6R,3Z)-3-benzylidene-6-isobutyl-1-methyl piperazine-2,5-dione (1), as well as five known DKPs 2-6 was isolated from a deep sea-derived Streptomyces sp. SCSIO 04496. The structure of 1 was elucidated using a combination of 1D and 2D NMR, HR-ESI-MS and chiral-phase HPLC techniques. Compounds 1-6 did not show cytotoxic activity at a concentration of 100 μM in bioactivity assay.
Keywords:
Streptomyces sp.; cyclodipeptide; diketopiperazine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzylidene Compounds / chemistry*
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Benzylidene Compounds / isolation & purification
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Benzylidene Compounds / pharmacology*
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Cell Line, Tumor / drug effects
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Chromatography, High Pressure Liquid
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Diketopiperazines / chemistry*
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Diketopiperazines / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Oceans and Seas
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Piperazines / chemistry*
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Piperazines / isolation & purification
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Piperazines / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
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Streptomyces / chemistry*
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Streptomyces / isolation & purification
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Water Microbiology
Substances
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3-benzylidene-6-isobutyl-1-methyl piperazine-2,5-dione
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Benzylidene Compounds
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Diketopiperazines
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Piperazines