A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy

Adv Mater. 2015 Sep 9;27(34):5034-42. doi: 10.1002/adma.201501502. Epub 2015 Jul 21.

Abstract

Novel core-shell tumor-penetrating vesicles consisting of a nanovesicle core with tumor-penetrating ligands and enzymatically degradable polymeric peptides anchored covalently to the core to form a thin polymeric shell are evaluated as drug-delivery systems. This delivery platform demonstrates an enhanced therapeutic efficacy attributed to the synergistic contributions from matrix metalloproteinase (MMP)-responsive drug release as well as improved tumor accumulation and penetration in the tumor microenvironment.

Keywords: drug delivery; peptides; polymers; self-assembly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Transport
  • Cell-Penetrating Peptides / chemistry*
  • Cell-Penetrating Peptides / metabolism*
  • Drug Carriers / chemistry*
  • Drug Carriers / metabolism*
  • Female
  • HT29 Cells
  • Humans
  • MCF-7 Cells
  • Mice
  • Models, Molecular
  • Molecular Conformation
  • Nanomedicine*
  • Nanostructures / chemistry*
  • Oligopeptides / chemistry
  • Tumor Microenvironment*

Substances

  • Cell-Penetrating Peptides
  • Drug Carriers
  • Oligopeptides
  • arginyl-glycyl-aspartic acid