Ultrasmall Gold Nanorod Vesicles with Enhanced Tumor Accumulation and Fast Excretion from the Body for Cancer Therapy

Adv Mater. 2015 Sep 2;27(33):4910-7. doi: 10.1002/adma.201502486. Epub 2015 Jul 21.

Abstract

A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (≈60 nm) (AuNR = gold nanorod; PEG = poly(ethylene glycol); PLGA = poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: ≈8 nm × 2 nm) is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion from the body as AuNR@PEG after therapy; enhanced photoacoustic and photo thermal properties; and high photothermal cancer therapy efficacy.

Keywords: biodegradation; nanovesicles; photoacoustic imaging; photothermal effects; ultrasmall gold nanorods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / metabolism*
  • Brain Neoplasms / therapy*
  • Cell Line, Tumor
  • Gold / chemistry*
  • Gold / metabolism*
  • Gold / pharmacokinetics
  • Humans
  • Kinetics
  • Lactic Acid / chemistry
  • Mice
  • Nanotubes*
  • Photoacoustic Techniques
  • Polyethylene Glycols / chemistry
  • Polyglycolic Acid / chemistry
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Theranostic Nanomedicine*

Substances

  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Lactic Acid
  • Polyethylene Glycols
  • Gold