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, 10 (6), 878-80

Translocator Protein 18 kDa (TSPO): Old Dogma, New Mice, New Structure, and New Questions for Neuroprotection

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Translocator Protein 18 kDa (TSPO): Old Dogma, New Mice, New Structure, and New Questions for Neuroprotection

Eun-Jung Kim et al. Neural Regen Res.

Figures

Figure 1
Figure 1
Two different types of microglial activation modulated by high expression levels of translocator protein 18 kDa (TSPO) or its ligand during neuroinflammation. The TSPO level is elevated in activated microglia. Binding of TSPO to its ligand, or up-regulation of its expression level, enhances alternative M2 anti-in-flammatory microglial activation. M2 polarization results in more phagocytic activity and the up-regulation of anti-inflammatory genes to resolve neuroin-flammation and promote recovery from tissue damage. In contrast, M1 pro-inflammatory microglial activation seems to be reduced by the up-regulation of TSPO or its ligand.

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Cited by 4 PubMed Central articles

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