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, 10 (6), 878-80

Translocator Protein 18 kDa (TSPO): Old Dogma, New Mice, New Structure, and New Questions for Neuroprotection


Translocator Protein 18 kDa (TSPO): Old Dogma, New Mice, New Structure, and New Questions for Neuroprotection

Eun-Jung Kim et al. Neural Regen Res.


Figure 1
Figure 1
Two different types of microglial activation modulated by high expression levels of translocator protein 18 kDa (TSPO) or its ligand during neuroinflammation. The TSPO level is elevated in activated microglia. Binding of TSPO to its ligand, or up-regulation of its expression level, enhances alternative M2 anti-in-flammatory microglial activation. M2 polarization results in more phagocytic activity and the up-regulation of anti-inflammatory genes to resolve neuroin-flammation and promote recovery from tissue damage. In contrast, M1 pro-inflammatory microglial activation seems to be reduced by the up-regulation of TSPO or its ligand.

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    1. Bae KR, Shim HJ, Balu D, Kim SR, Yu SW. Translocator protein 18 kDa negatively regulates inflammation in microglia. J Neuroimmune Pharmacol. 2014;9:424–437. - PubMed
    1. Banati RB. Visualising microglial activation in vivo. Glia. 2002;40:206–217. - PubMed
    1. Banati RB, Middleton RJ, Chan R, Hatty CR, Kam WWY, Quin C, Graeber MB, Parmar A, Zahra D, Callaghan P, Fok S, Howell NR, Gregoire M, Szabo A, Pham T, Davis E, Liu GJ. Positron emission tomography and functional characterization of a complete PBR/TSPO knockout. Nat Commun. 2014;5:5452. - PMC - PubMed
    1. Guo Y, Kalathur RC, Liu Q, Kloss B, Bruni R, Ginter C, Kloppmann E, Rost B, Hendrickson WA. Structure and activity of tryptophan-rich TSPO proteins. Science. 2015;347:551–555. - PMC - PubMed
    1. Jaremko Ł, Jaremko M, Giller K, Becker S, Zweckstetter M. Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science. 2014;343:1363–1366. - PMC - PubMed