Comparison of ferrous sulfate, polymaltose complex and iron-zinc in iron deficiency anemia

Minerva Pediatr. 2019 Oct;71(5):449-454. doi: 10.23736/S0026-4946.17.04268-2. Epub 2015 Jul 22.


Background: The purpose of this study was to compare the effectiveness of different oral iron preparations in children with iron deficiency anemia (IDA).

Methods: Sixty children with IDA, aged between 6 months and 180 months, were randomly assigned into three treatment groups. Group I included children with IDA who received ferrous sulfate (Fe-S); Group II included children receiving iron polymaltose complexes (Fe-OH-PM), and Group III included children receiving a single preparation of combined iron and zinc (Fe-Zn). The effect of different iron preparations were evaluated and compared. The duration of treatment was 8 weeks. Hemoglobin (Hgb) levels, as well as other hematological parameters were determined at admission and the first, fourth, and eighth weeks of the treatment.

Results: The Hgb levels of patients in all three groups were statistically higher in the fourth (P=0.001) and eighth (P<0.001) weeks compared to baseline; although there was no difference between the groups at the end of the treatment period (P>0.05).

Conclusions: Our results indicate that, Fe-OH-PM and Fe-Zn preparations may also be preferred as a choice like Fe-S for treatment of children with IDA.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adolescent
  • Anemia, Iron-Deficiency / drug therapy*
  • Child
  • Child, Preschool
  • Female
  • Ferric Compounds / administration & dosage*
  • Ferrous Compounds / administration & dosage*
  • Hematinics / administration & dosage
  • Hemoglobins / metabolism
  • Humans
  • Infant
  • Male
  • Treatment Outcome
  • Zinc / administration & dosage*


  • Ferric Compounds
  • Ferrous Compounds
  • Hematinics
  • Hemoglobins
  • ferrous sulfate
  • Zinc
  • teferrol