Exploration of Dimethylzinc-Mediated Radical Reactions

Ken-Ichi Yamada; Kiyoshi Tomioka

doi:10.1002/tcr.201500017

Exploration of Dimethylzinc-Mediated Radical Reactions

Chem Rec. 2015 Oct;15(5):854-71. doi: 10.1002/tcr.201500017. Epub 2015 Jul 17.

Authors

Ken-Ichi Yamada¹, Kiyoshi Tomioka²

Affiliations

¹ Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan. yamak@pharm.kyoto-u.ac.jp.
² Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyoto, Japan. ktomioka@dwc.doshisha.ac.jp.

PMID: 26201084
DOI: 10.1002/tcr.201500017

Abstract

In this account, our studies on radical reactions that are promoted by dimethylzinc and air are described. Advantages of this reagent and differences from conventional radical initiators, such as triethylborane, are discussed.

Keywords: C(sp3)-H bond functionalization; carbon-carbon bond formation; dimethylzinc; radical reactions; umpolung.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Boranes / chemical synthesis*
Boranes / chemistry
Free Radicals / chemical synthesis
Free Radicals / chemistry
Molecular Structure
Organometallic Compounds / chemistry*
Zinc / chemistry*

Substances

Boranes
Free Radicals
Organometallic Compounds
Zinc
triethylborane