Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049)

Clin Endocrinol (Oxf). 2015 Dec;83(6):902-12. doi: 10.1111/cen.12864. Epub 2015 Sep 3.


Objective: To study the association between serum anti-Müllerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5·2-12·1 μg/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a GnRH antagonist protocol.

Design: Secondary analysis of a randomized controlled trial with stratified randomization according to AMH (lower stratum: 5·0-14·9 pmol/l; higher stratum: 15·0-44·9 pmol/l).

Patients: Infertile women of good prognosis (n = 265).

Measurements: Follicular development and endocrine parameters during controlled ovarian stimulation (COS) with rhFSH.

Results: Serum FSH levels increased with increasing rhFSH doses and steady-state levels for each dose were similar in both AMH strata. In the whole study population, significant (P < 0·001) positive dose responses were observed for the number of follicles ≥ 12 mm, and serum levels of oestradiol, inhibin B, inhibin A and progesterone at end of stimulation. In comparison with the higher AMH stratum, patients in the lower AMH stratum had significantly different slopes of the dose-response curves for these hormones, and no clear dose-related increase was observed for the number of follicles in these patients.

Conclusions: Dose-response relationships between rhFSH and follicular development and endocrine parameters are significantly different for IVF/ICSI patients with lower and higher serum AMH levels at start of COS.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-Mullerian Hormone / blood*
  • Female
  • Fertilization in Vitro
  • Follicle Stimulating Hormone / blood
  • Follicle Stimulating Hormone / therapeutic use*
  • Humans
  • Ovulation Induction / methods
  • Pregnancy
  • Young Adult


  • Anti-Mullerian Hormone
  • Follicle Stimulating Hormone