Type 2 responses at the interface between immunity and fat metabolism

Curr Opin Immunol. 2015 Oct;36:67-72. doi: 10.1016/j.coi.2015.07.003. Epub 2015 Jul 21.

Abstract

Adipose tissue resident leukocytes are often cast solely as the effectors of obesity and its attendant pathologies; however, recent observations have demonstrated that these cells support and effect 'healthy' physiologic function as well as pathologic dysfunction. Importantly, these two disparate outcomes are underpinned by similarly disparate immune programs; type 2 responses instruct and promote metabolic normalcy, while type 1 responses drive tissue dysfunction. In this Review, we summarize the literature regarding type 2 immunity's role in adipose tissue physiology and allude to its potential therapeutic implications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity
  • Adipose Tissue / immunology
  • Adipose Tissue / metabolism
  • Animals
  • Fats / metabolism*
  • Homeostasis
  • Humans
  • Immunity*
  • Immunity, Innate
  • Lipid Metabolism*
  • Macrophages / immunology
  • Macrophages / metabolism
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism

Substances

  • Fats