Cisplatin is a neurotoxic chemotherapeutic agent known to cause sensory peripheral neuropathy or ototoxicity. We report a patient with an oropharynx carcinoma who developed a multifocal, necrotizing leukoencephalopathy after cisplatin treatment. This indicates that cisplatin can induce, similar to other chemotherapeutic agents, demyelinating, necrotizing lesions in the white matter of the cerebrum.