Adiposity and cancer risk: new mechanistic insights from epidemiology

Nat Rev Cancer. 2015 Aug;15(8):484-98. doi: 10.1038/nrc3967.


Excess body adiposity, commonly expressed as body mass index (BMI), is a risk factor for many common adult cancers. Over the past decade, epidemiological data have shown that adiposity-cancer risk associations are specific for gender, site, geographical population, histological subtype and molecular phenotype. The biological mechanisms underpinning these associations are incompletely understood but need to take account of the specificities observed in epidemiology to better inform future prevention strategies.

Publication types

  • Review

MeSH terms

  • Adiposity
  • Animals
  • Body Mass Index
  • Humans
  • Incidence
  • Inflammation / metabolism
  • Inflammation / pathology
  • Neoplasms / epidemiology
  • Neoplasms / etiology*
  • Obesity / complications*
  • Obesity / pathology
  • Risk Factors