Bis(monoacylglycero)phosphate as a Macrophage Enriched Phospholipid

Lipids. 2015 Sep;50(9):907-12. doi: 10.1007/s11745-015-4045-5. Epub 2015 Jul 24.

Abstract

Bis(monoacylglycero)phosphate (BMP) is a structural isomer of phosphatidylglycerol (PtdGro) with an unusual sn-1:sn-1' fatty acyl configuration and is found almost exclusively in late endosomes/lysosomes. BMP comprises only about 1-2% of the total phospholipids in most mammalian cells, but accumulates in tissues of humans and animals with lysosomal storage disorders including the gangliosidoses. Total BMP content was significantly greater in cells of macrophage/microglial origin than in cells of macroglial origin. BMP composition was similar in tumorigenic/metastatic macrophages and non-tumorigenic macrophages/microglia. Finally, BMP fatty acid composition differed between cells grown in culture and obtained in vivo suggesting an influence from growth environment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Humans
  • Lysophospholipids / chemistry*
  • Macrophages / chemistry*
  • Mice
  • Monoglycerides / chemistry*
  • Phospholipids / chemistry*

Substances

  • Lysophospholipids
  • Monoglycerides
  • Phospholipids
  • bis(monoacylglyceryl)phosphate