Abstract
Background:
The Chines herb derived Sparstolonin B, (SsnB), is a recently identified natural compound that selectively blocks TLR2- and TLR4-mediated inflammatory signaling. But it is unknown whether this compound has any effect on HIV infection.
Findings:
We found that SsnB treatment blocked HIV-1 transcription via a novel mechanism that requires the TAR region. Treatment of human T cell lines or peripheral blood mononuclear cells with SsnB at 1 μM significantly inhibited HIV production. Lastly, SsnB was able to inhibit HIV in synergy with AZT.
Conclusions:
These data suggest that SsnB is a novel natural compound that inhibits HIV-1 transcription and may be a new drug in the treatment of HIV infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology*
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Biological Products / isolation & purification
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Biological Products / pharmacology
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Cells, Cultured
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Drug Synergism
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HIV-1 / drug effects*
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HIV-1 / physiology
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Heterocyclic Compounds, 4 or More Rings / isolation & purification*
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Heterocyclic Compounds, 4 or More Rings / pharmacology*
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Humans
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Plants, Medicinal / chemistry*
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T-Lymphocytes / drug effects
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T-Lymphocytes / virology
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Transcription, Genetic / drug effects*
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Virus Replication / drug effects
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Zidovudine / pharmacology
Substances
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Anti-HIV Agents
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Biological Products
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Heterocyclic Compounds, 4 or More Rings
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sparstolonin B
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Zidovudine