Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Sep;39 Suppl 1(0 1):S60-3.
doi: 10.1016/j.clinre.2015.06.015. Epub 2015 Jul 20.

Reversibility of Liver Fibrosis

Affiliations
Free PMC article
Review

Reversibility of Liver Fibrosis

Mengxi Sun et al. Clin Res Hepatol Gastroenterol. .
Free PMC article

Abstract

Liver fibrosis is a serious health problem worldwide, which can be induced by a wide spectrum of chronic liver injuries. However, until today, there is no effective therapy available for liver fibrosis except the removal of underlying etiology or liver transplantation. Recent studies indicate that liver fibrosis is reversible when the causative agent(s) is removed. Understanding of mechanisms of liver fibrosis regression will lead to the identification of new therapeutic targets for liver fibrosis. This review summarizes recent research progress on mechanisms of reversibility of liver fibrosis. While most of the research has been focused on HSCs/myofibroblasts and inflammatory pathways, the crosstalk between different organs, various cell types and multiple signaling pathways should not be overlooked. Future studies that lead to fully understanding of the crosstalk between different cell types and the molecular mechanism underlying the reversibility of liver fibrosis will definitely give rise to new therapeutic strategies to treat liver fibrosis.

Conflict of interest statement

Conflict of interests: none to declare

Similar articles

See all similar articles

Cited by 44 articles

See all "Cited by" articles

Publication types

Feedback