In vitro activity of tedizolid against gram-positive bacteria in patients with skin and skin structure infections and hospital-acquired pneumonia: a Korean multicenter study

Ann Lab Med. 2015 Sep;35(5):523-30. doi: 10.3343/alm.2015.35.5.523.

Abstract

We compared the activities of tedizolid to those of linezolid and other commonly used antimicrobial agents against gram-positive cocci recovered from patients with skin and skin structure infections (SSSIs) and hospital-acquired pneumonia (HAP) in Korean hospitals. Gram-positive isolates were collected from 356 patients with SSSIs and 144 patients with HAP at eight hospitals in Korea from 2011 to 2014. SSSIs included impetigo, cellulitis, erysipelas, furuncles, abscesses, and infected burns. Antimicrobial susceptibility was tested by using the CLSI agar dilution method. All of the gram-positive isolates were inhibited by ≤1 μg/mL tedizolid. The minimum inhibitory concentration [MIC]₉₀ of tedizolid was 0.5 μg/mL for methicillin-resistant Staphylococcus aureus, which was 4-fold lower than that of linezolid. Tedizolid may become a useful option for the treatment of SSSIs and HAP caused by gram-positive bacteria.

Keywords: Gram-positive bacteria; Infection; Pneumonia; Skin; Soft tissue; Tedizolid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Asian Continental Ancestry Group
  • Gram-Positive Bacteria / drug effects*
  • Gram-Positive Bacteria / isolation & purification
  • Gram-Positive Bacterial Infections / diagnosis
  • Gram-Positive Bacterial Infections / microbiology
  • Hospitals
  • Humans
  • Linezolid / pharmacology
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Microbial Sensitivity Tests
  • Organophosphates / pharmacology*
  • Oxazoles / pharmacology*
  • Pneumonia / diagnosis
  • Pneumonia / microbiology*
  • Republic of Korea
  • Skin / microbiology*
  • Skin Diseases / diagnosis
  • Skin Diseases / microbiology*

Substances

  • Anti-Bacterial Agents
  • Organophosphates
  • Oxazoles
  • Linezolid
  • tedizolid phosphate