Challenges, Progresses, and Promises for Developing Future NADPH Oxidase Therapeutics

Antioxid Redox Signal. 2015 Aug 10;23(5):355-7. doi: 10.1089/ars.2015.6450.


NADPH oxidase (NOX) enzymes show great potential as therapeutic pharmacological targets. This Forum revolves around the roles of specific NOX isoforms in oxidative stress-mediated pathologies, available NOX antagonists/agonists as well as the potential side effects of NOX inhibition and the requisite identification of novel oxidative biomarkers as a measure of NOX activity in patients. In addition, an original article reports the discovery of a novel small molecule NOX2 inhibitor. Finally an attractive and innovative therapeutic approach for modulating NOX activity through the inhibition of the proton channel Hv1 is discussed.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Discovery*
  • Humans
  • Ion Channels / metabolism
  • NADPH Oxidases / therapeutic use*
  • Oxidative Stress


  • HVCN1 protein, human
  • Ion Channels
  • NADPH Oxidases