Increased IL-3 serum levels in chronic patients with schizophrenia: Associated with psychopathology

Psychiatry Res. 2015 Sep 30;229(1-2):225-9. doi: 10.1016/j.psychres.2015.07.029. Epub 2015 Jul 16.


Schizophrenia is associated with the inflammation-related pathways, including aberrant cytokines levels. In this study, we examined the association of serum IL-3 levels with psychopahological symtoms in chronic schizophrenia. Serum IL-3 levels were assessed in 42 patients diagnosed with schizophrenia and compared to 43 healthy control subjects matched for age and gender. Schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS), and serum IL-3 levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA). Our results showed that IL-3 levels were significantly increased in patients with chronic schizophrenia compared to healthy control subjects. Correlation analysis revealed a significant positive correlation between the IL-3 levels and the PANSS general subscore. Moreover, IL-3 levels were significantly positively correlated with depressive subscore. Our results suggested that IL-3 related pathway is associated with psychopathology of schizophrenia patients.

Keywords: Cytokines; Immune system; Interleukin-3; Psychopathology; Schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chronic Disease
  • Depressive Disorder / diagnosis
  • Depressive Disorder / immunology
  • Depressive Disorder / psychology
  • Female
  • Humans
  • Interleukin-3 / blood*
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales
  • Psychopathology
  • Schizophrenia / diagnosis
  • Schizophrenia / immunology*
  • Schizophrenic Psychology*
  • Statistics as Topic


  • Interleukin-3