The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology

Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1502-9. doi: 10.1016/j.bbapap.2015.07.009. Epub 2015 Jul 21.

Abstract

The aim of this mini-review is to draw together the main concepts and findings that have emerged from recent studies of the cardiac channel protein Nav1.5. This complex protein is encoded by the SCN5A gene that, in its mutated form, is implicated in various diseases, particularly channelopathies, specifically at cardiac tissue level. Here we describe the structural, and functional aspects of Nav1.5 including post-translational modifications in normal conditions, and the main human channelopathies in which this protein may be the cause or trigger. Lastly, we also briefly discuss interacting proteins that are relevant for these channel functions in normal and disease conditions.

Keywords: Cardiac sodium channel; Channelopathies; Na(v)1.5; Na(v)1.5 biology; SCN5A; Sodium channel kinetics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Membrane / metabolism*
  • Cell Membrane / pathology
  • Channelopathies / genetics
  • Channelopathies / metabolism*
  • Channelopathies / physiopathology
  • Gene Expression
  • Glycosylation
  • Humans
  • Mutation
  • Myocardium / metabolism
  • Myocardium / pathology
  • Myocytes, Cardiac / metabolism*
  • Myocytes, Cardiac / pathology
  • NAV1.5 Voltage-Gated Sodium Channel / chemistry
  • NAV1.5 Voltage-Gated Sodium Channel / genetics
  • NAV1.5 Voltage-Gated Sodium Channel / metabolism*
  • Protein Interaction Mapping
  • Protein Processing, Post-Translational*
  • Protein Structure, Tertiary
  • Protein Subunits / chemistry
  • Protein Subunits / genetics
  • Protein Subunits / metabolism*

Substances

  • NAV1.5 Voltage-Gated Sodium Channel
  • Protein Subunits
  • SCN5A protein, human