Proteobacteria: microbial signature of dysbiosis in gut microbiota

Trends Biotechnol. 2015 Sep;33(9):496-503. doi: 10.1016/j.tibtech.2015.06.011. Epub 2015 Jul 22.


Recent advances in sequencing techniques, applied to the study of microbial communities, have provided compelling evidence that the mammalian intestinal tract harbors a complex microbial community whose composition is a critical determinant of host health in the context of metabolism and inflammation. Given that an imbalanced gut microbiota often arises from a sustained increase in abundance of the phylum Proteobacteria, the natural human gut flora normally contains only a minor proportion of this phylum. Here, we review studies that explored the association between an abnormal expansion of Proteobacteria and a compromised ability to maintain a balanced gut microbial community. We also propose that an increased prevalence of Proteobacteria is a potential diagnostic signature of dysbiosis and risk of disease.

Keywords: Proteobacteria; dysbiosis; microbiota.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dysbiosis / microbiology*
  • Environmental Microbiology
  • Gastrointestinal Microbiome*
  • Humans
  • Proteobacteria*