Cell membrane-camouflaged nanoparticles for drug delivery

J Control Release. 2015 Dec 28;220(Pt B):600-7. doi: 10.1016/j.jconrel.2015.07.019. Epub 2015 Jul 23.


Nanoparticles can preferentially accumulate at sites of action and hold great promise to improve the therapeutic index of many drugs. While conventional methods of nanocarrier-mediated drug delivery have focused on primarily synthetic approaches, engineering strategies that combine synthetic nanoparticles with natural biomaterials have recently gained much attention. In particular, cell membrane-camouflaged nanoparticles are a new class of biomimetic nanoparticles that combine the unique functionalities of cellular membranes and engineering versatility of synthetic nanomaterials for effective delivery of therapeutic agents. Herein, we report on the recent progress on cell membrane-coated nanoparticles for drug delivery. In particular, we highlight three areas: (i) prolonging systemic circulation via cell membrane coating, (ii) cell-specific targeting via cell membrane coating, and (iii) applications of cell membrane coating for drug delivery. The cell membrane-camouflaged nanoparticle platform has emerged as a novel delivery strategy with the potential to improve the therapeutic efficacy for the treatment of a variety of diseases.

Keywords: Biomimetic nanoparticle; Cell membrane; Drug delivery; Nanomedicine; Targeted delivery.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomimetic Materials*
  • Biomimetics
  • Cell Membrane / chemistry*
  • Cell Membrane / metabolism
  • Drug Carriers*
  • Humans
  • Nanoparticles*
  • Nanotechnology
  • Pharmaceutical Preparations / administration & dosage*
  • Pharmaceutical Preparations / chemistry
  • Pharmaceutical Preparations / metabolism
  • Pharmacokinetics


  • Drug Carriers
  • Pharmaceutical Preparations