APOA II genotypes frequency and their interaction with saturated fatty acids consumption on lipid profile of patients with type 2 diabetes

Clin Nutr. 2016 Aug;35(4):907-11. doi: 10.1016/j.clnu.2015.06.008. Epub 2015 Jul 16.


Background & aim: Several studies have suggested that APOA II-265T/C polymorphism affect lipid profile. The aim of this study was to investigate the effect of -265T/C APOA II polymorphism and saturated fatty acids (SFA) intake interaction on lipid profile in diabetic population who are at risk for lipid disorders.

Methods: In this cross sectional study, 697 type 2 diabetic patients participated. Food consumption data were collected using validated semi-quantitative FFQ during the last year. Realtime-PCR was used to determine APOA II-265T/C genotypes. The interaction between the genotypes and SFA intake with lipid profile was tested using analysis of covariance (ANCOVA).

Results: According to APOA II-265T/C (rs5082) genotype distribution results, CC genotype with a frequency of 12.9% and TC with that of 47.7% showed the lowest and highest frequency in our population, respectively. CC genotype subjects had significantly lower total cholesterol, triglyceride, Cholesterol/HDL-c ratio and non-HDL cholesterol than T allele carriers (p = 0.009, p = 0.02, p = 0.02 and p = 0.002, respectively). The interaction between genotype and SFA intake contributed to significant higher levels of LDL-c and LDL/HDL in CCs (p = 0.05 and p = 0.01), suggesting vulnerability of these individuals to high intake of SFA in the diet.

Conclusion: APOA II polymorphism may influence the saturated fatty acid intake required to prevent dyslipidemia in the type 2 diabetic population.

Keywords: Apolipoprotein A II; Diabetes type 2; Lipid profiles; Saturated fatty acids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Apolipoprotein A-II / blood
  • Apolipoprotein A-II / genetics*
  • Cholesterol / blood*
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / blood*
  • Diet*
  • Exercise
  • Fatty Acids / administration & dosage*
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Nutrition Assessment
  • Polymorphism, Genetic
  • Triglycerides / blood


  • Apolipoprotein A-II
  • Fatty Acids
  • Triglycerides
  • Cholesterol