The benzodiazepines

Am Fam Physician. 1978 May;17(5):131-4.

Abstract

The benzodiazepines are remarkably effective anxiolytic drugs. However, they are prone to misuse by both physicians and patients. They should be used in clearly defined clinical situations for short periods, at the lowest possible dosages. Although rare, toxicity can be severe. These agents should be used with caution in persons likely to abuse medication, in the elderly, in patients with glaucoma and in patiens with known hepatic impairment. Sudden cessation may be followed by a withdrawal state.

MeSH terms

  • Anti-Anxiety Agents / adverse effects
  • Anti-Anxiety Agents / metabolism
  • Anti-Anxiety Agents / pharmacology*
  • Chlordiazepoxide / metabolism
  • Diazepam / metabolism
  • Humans
  • Substance Withdrawal Syndrome
  • Substance-Related Disorders

Substances

  • Anti-Anxiety Agents
  • Chlordiazepoxide
  • Diazepam