Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

Nat Neurosci. 2015 Sep;18(9):1230-2. doi: 10.1038/nn.4068. Epub 2015 Jul 27.


It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Basal Forebrain / chemistry
  • Basal Forebrain / metabolism
  • Female
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neural Pathways / chemistry
  • Neural Pathways / metabolism
  • Nucleus Accumbens / chemistry
  • Nucleus Accumbens / metabolism*
  • Optogenetics / methods
  • Receptors, Dopamine D1 / analysis
  • Receptors, Dopamine D1 / biosynthesis*
  • Receptors, Dopamine D1 / genetics
  • Receptors, Dopamine D2 / analysis
  • Receptors, Dopamine D2 / biosynthesis*
  • Receptors, Dopamine D2 / genetics


  • Receptors, Dopamine D1
  • Receptors, Dopamine D2