Effectiveness of Lateral Bone Augmentation on the Alveolar Crest Dimension: A Systematic Review and Meta-analysis

J Dent Res. 2015 Sep;94(9 Suppl):128S-42S. doi: 10.1177/0022034515594780. Epub 2015 Jul 27.


Lateral ridge augmentation procedures are aimed to reconstruct deficient alveolar ridges or to build up peri-implant dehiscence and fenestrations. The objective of this systematic review was to assess the efficacy of these interventions by analyzing data from 40 clinical studies evaluating bone augmentation through either the staged or the simultaneous approach. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guideline for systematic reviews was used. The primary outcomes were the changes at reentry, in the ridge width, and in the vertical and horizontal dimensions of the peri-implant defect, measured in millimeters, in the staged and simultaneous approaches, respectively. The results of the meta-analysis showed, for the simultaneous approach, a statistically significant defect height reduction when all treatments were analyzed together (weighted mean difference [WMD] = -4.28 mm; 95% confidence interval: [CI] -4.88, -3.69; P < 0.01). The intervention combining bone replacement grafts with barrier membranes was associated with superior outcomes The most frequently used intervention was the combination of xenograft and bioabsorbable membrane. Similarly, for the staged approach, there was a statistically significant horizontal gain when all treatment groups were combined (WMD = 3.90 mm; 95% CI: 3.52, 4.28; P < 0.001). The most frequently used intervention was the use of autogenous bone blocks. Both treatment strategies led to high survival and success rates (>95%) for the implants placed on the regenerated sites. Nonexposed sites gained significantly more in the simultaneous and staged approaches (WMD = 1.1 and 3.1 mm).

Keywords: alveolar bone loss; alveolar ridge augmentation; bone regeneration; bone substitutes; bone transplantation; dental implant.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Alveolar Process / pathology*
  • Alveolar Ridge Augmentation / methods
  • Alveolar Ridge Augmentation / standards*
  • Bone Transplantation / methods
  • Dental Implantation, Endosseous / methods
  • Guided Tissue Regeneration, Periodontal / methods
  • Guided Tissue Regeneration, Periodontal / standards
  • Humans
  • Membranes, Artificial
  • Treatment Outcome


  • Membranes, Artificial