Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Sep;33(9):504-13.
doi: 10.1016/j.tibtech.2015.06.007. Epub 2015 Jul 24.

Bioprinting for Cancer Research


Bioprinting for Cancer Research

Stephanie Knowlton et al. Trends Biotechnol. .


Bioprinting offers the ability to create highly complex 3D architectures with living cells. This cutting-edge technique has significantly gained popularity and applicability in several fields. Bioprinting methods have been developed to effectively and rapidly pattern living cells, biological macromolecules, and biomaterials. These technologies hold great potential for applications in cancer research. Bioprinted cancer models represent a significant improvement over previous 2D models by mimicking 3D complexity and facilitating physiologically relevant cell-cell and cell-matrix interactions. Here we review bioprinting methods based on inkjet, microextrusion, and laser technologies and compare 3D cancer models with 2D cancer models. We discuss bioprinted models that mimic the tumor microenvironment, providing a platform for deeper understanding of cancer pathology, anticancer drug screening, and cancer treatment development.

Similar articles

  • Bioprinting technologies for disease modeling.
    Memic A, Navaei A, Mirani B, Cordova JAV, Aldhahri M, Dolatshahi-Pirouz A, Akbari M, Nikkhah M. Memic A, et al. Biotechnol Lett. 2017 Sep;39(9):1279-1290. doi: 10.1007/s10529-017-2360-z. Epub 2017 May 26. Biotechnol Lett. 2017. PMID: 28550360 Review.
  • Biomaterials for integration with 3-D bioprinting.
    Skardal A, Atala A. Skardal A, et al. Ann Biomed Eng. 2015 Mar;43(3):730-46. doi: 10.1007/s10439-014-1207-1. Epub 2014 Dec 5. Ann Biomed Eng. 2015. PMID: 25476164 Review.
  • Bioprinting the Cancer Microenvironment.
    Zhang YS, Duchamp M, Oklu R, Ellisen LW, Langer R, Khademhosseini A. Zhang YS, et al. ACS Biomater Sci Eng. 2016 Oct 10;2(10):1710-1721. doi: 10.1021/acsbiomaterials.6b00246. Epub 2016 Jun 17. ACS Biomater Sci Eng. 2016. PMID: 28251176 Free PMC article.
  • Emerging tumor spheroids technologies for 3D in vitro cancer modeling.
    Rodrigues T, Kundu B, Silva-Correia J, Kundu SC, Oliveira JM, Reis RL, Correlo VM. Rodrigues T, et al. Pharmacol Ther. 2018 Apr;184:201-211. doi: 10.1016/j.pharmthera.2017.10.018. Epub 2017 Oct 31. Pharmacol Ther. 2018. PMID: 29097309 Review.
  • Engineering Breast Cancer Microenvironments and 3D Bioprinting.
    Belgodere JA, King CT, Bursavich JB, Burow ME, Martin EC, Jung JP. Belgodere JA, et al. Front Bioeng Biotechnol. 2018 May 24;6:66. doi: 10.3389/fbioe.2018.00066. eCollection 2018. Front Bioeng Biotechnol. 2018. PMID: 29881724 Free PMC article. Review.
See all similar articles

Cited by 47 articles

See all "Cited by" articles

Publication types

LinkOut - more resources