Centhaquin Improves Survival in a Swine Model of Hemorrhagic Shock

J Surg Res. 2016 Jan;200(1):227-35. doi: 10.1016/j.jss.2015.06.056. Epub 2015 Jun 29.

Abstract

Background: Hemorrhage is a frequent event in hospital and prehospital settings. The aim of the present study was to investigate whether centhaquin improves 24-h survival and reduces the total volume of required fluids in an established model of swine hemorrhagic shock.

Material and methods: Twenty-five pigs were instrumented and subjected to hemorrhagic shock. The animals were randomly allocated in two experimental groups, the control (vehicle) (n = 10) and the centhaquin groups (0.015 mg/kg, n = 10); all animals received lactated Ringer solution in the resuscitation phase until their mean arterial pressure reached 90% of the baseline. A sham group (n = 5) was added a posteriori to mimic the hemodynamic profile of the centhaquin group.

Results: A statistically significant difference was observed in the time required for the three groups to reach their target mean aortic pressure, 36.88 ± 3.26 min for the control group versus 9.40 ± 1.01 min for the sham group and 7.10 ± 0.97 min for the centhaquin group (P < 0.001). The total amount of fluids in the control and the sham groups was significantly higher when compared with that of the centhaquin-treated animals (P < 0.001). All 10 animals in the centhaquin group survived for 24 h, whereas only three animals survived in the control group and one animal in the sham group (P = 0.002).

Conclusions: Centhaquin 0.015 mg/kg administered in the fluid resuscitation phase resulted in lower volume of fluids and better survival compared with control and sham-operated animals.

Keywords: Centhaquin; Fluids; Hemorrhagic shock; Resuscitation; Survival.

Publication types

  • Evaluation Study

MeSH terms

  • Animals
  • Combined Modality Therapy
  • Female
  • Fluid Therapy / methods*
  • Isotonic Solutions / therapeutic use
  • Kaplan-Meier Estimate
  • Piperazines / therapeutic use*
  • Protective Agents / therapeutic use*
  • Random Allocation
  • Resuscitation / methods*
  • Ringer's Lactate
  • Shock, Hemorrhagic / mortality
  • Shock, Hemorrhagic / therapy*
  • Swine
  • Treatment Outcome

Substances

  • Isotonic Solutions
  • Piperazines
  • Protective Agents
  • Ringer's Lactate
  • centhaquine