Myelination: actin disassembly leads the way

Dev Cell. 2015 Jul 27;34(2):129-30. doi: 10.1016/j.devcel.2015.07.006.


The mechanisms that drive the spiral wrapping of the myelin sheath around axons are poorly understood. Two papers in this issue of Developmental Cell demonstrate that actin disassembly, rather than actin assembly, predominates during oligodendrocyte maturation and is critical for the genesis of the central myelin sheath.

Publication types

  • Comment

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Actin-Related Protein 2-3 Complex / metabolism*
  • Animals
  • Central Nervous System / growth & development*
  • Myelin Sheath / physiology*
  • Oligodendroglia / physiology*


  • Actin-Related Protein 2-3 Complex