Coenzyme Q Protects Against Age-Related Alveolar Bone Loss Associated to n-6 Polyunsaturated Fatty Acid Rich-Diets by Modulating Mitochondrial Mechanisms

J Gerontol A Biol Sci Med Sci. 2016 May;71(5):593-600. doi: 10.1093/gerona/glv063. Epub 2015 Jul 28.


An age-dependent model of the periodontium was reproduced to evaluate the effect of life-long feeding on a low coenzyme Q10 dosage in n-6, n-3 polyunsaturated fatty acid or monounsaturated fatty acid-based diets on periodontal tissues of young and old rats. Results shown that exacerbated age-related alveolar bone loss previously associated to n-6 polyunsaturated fatty acid diet was attenuated by coenzyme Q10 Gene expression analysis suggests that involved mechanisms might be related to a restored capacity of mitochondria to adapt to aging in gingival cells from rats fed on n-6 polyunsaturated fatty acid. In particular, this could be due to an age-related increase of the rate of mitochondrial biogenesis and a better oxidative and respiratory balance in these animals. From the nutritional and clinical point of view, it is noteworthy that supplementation with coenzyme Q10 could counteract the negative effects of n-6 polyunsaturated fatty acid on alveolar bone loss (a major feature of periodontitis) associated to age.

Keywords: Biogenesis; Electron transport chain; Fish oil; Sunflower oil; Virgin olive oil.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alveolar Bone Loss / etiology
  • Alveolar Bone Loss / prevention & control*
  • Animals
  • Diet / adverse effects*
  • Disease Models, Animal
  • Fatty Acids, Omega-6 / adverse effects*
  • Male
  • Osteoporosis / etiology
  • Osteoporosis / prevention & control*
  • Rats
  • Rats, Wistar
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / therapeutic use
  • Vitamins / therapeutic use*


  • Fatty Acids, Omega-6
  • Vitamins
  • Ubiquinone
  • coenzyme Q10